Multimodal monitoring of human brain organoids implanted in mice using transparent microelectrodes

Martin Thunemann; Madison Wilson; Francesca Puppo; Donald P. Pizzo; Hannah Rickner; Emma Bortz; Abed Al Fatah Mansour; Benjamin Wolozin; Xue Han; Fred H. Gage; Alysson R. Muotri; Duygu Kuzum; Anna Devor

Multimodal monitoring of human brain organoids implanted in mice using transparent microelectrodes

Martin Thunemann^*, Madison Wilson, Francesca Puppo, Donald P. Pizzo, Hannah Rickner, Emma Bortz, Abed Al Fatah Mansour, Benjamin Wolozin, Xue Han, Fred H. Gage, Alysson R. Muotri, Duygu Kuzum, Anna Devor

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

Abstract

We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.

Original language	American English
Article number	BM2B.4
Journal	Optics InfoBase Conference Papers
State	Published - 2021
Externally published	Yes
Event	Optics and the Brain, BRAIN 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 - Virtual, Online, United States Duration: 12 Apr 2021 → 16 Apr 2021

Bibliographical note

Funding Information:
This work was supported by NIH BRAIN Initiative Grant R21EY030727. We thank Q. Cheng for help with surgery.

Publisher Copyright:
© 2021 The Author(s).

Cite this

@article{9eb4b370fb304236aaec208411ebaf97,

title = "Multimodal monitoring of human brain organoids implanted in mice using transparent microelectrodes",

abstract = "We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.",

author = "Martin Thunemann and Madison Wilson and Francesca Puppo and Pizzo, {Donald P.} and Hannah Rickner and Emma Bortz and Mansour, {Abed Al Fatah} and Benjamin Wolozin and Xue Han and Gage, {Fred H.} and Muotri, {Alysson R.} and Duygu Kuzum and Anna Devor",

note = "Funding Information: This work was supported by NIH BRAIN Initiative Grant R21EY030727. We thank Q. Cheng for help with surgery. Publisher Copyright: {\textcopyright} 2021 The Author(s).; Optics and the Brain, BRAIN 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 ; Conference date: 12-04-2021 Through 16-04-2021",

year = "2021",

language = "American English",

journal = "Optics InfoBase Conference Papers",

issn = "2162-2701",

}

TY - JOUR

T1 - Multimodal monitoring of human brain organoids implanted in mice using transparent microelectrodes

AU - Thunemann, Martin

AU - Wilson, Madison

AU - Puppo, Francesca

AU - Pizzo, Donald P.

AU - Rickner, Hannah

AU - Bortz, Emma

AU - Mansour, Abed Al Fatah

AU - Wolozin, Benjamin

AU - Han, Xue

AU - Gage, Fred H.

AU - Muotri, Alysson R.

AU - Kuzum, Duygu

AU - Devor, Anna

PY - 2021

Y1 - 2021

N2 - We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.

AB - We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.

UR - http://www.scopus.com/inward/record.url?scp=85119677296&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:85119677296

SN - 2162-2701

JO - Optics InfoBase Conference Papers

JF - Optics InfoBase Conference Papers

M1 - BM2B.4

T2 - Optics and the Brain, BRAIN 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021

Y2 - 12 April 2021 through 16 April 2021

ER -

Multimodal monitoring of human brain organoids implanted in mice using transparent microelectrodes

Abstract

Bibliographical note

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