Abstract
This study assesses the feasibility of using a multiperturbation analysis (MPA) approach for lesion-symptom mapping. We analyze the relative contribution of damage in different brain regions to the expression of spatial neglect, as revealed in line-bisection performance. The data set comprised of normalized lesion information and bisection test results from 23 first-event right-hemisphere stroke patients. Obtaining quantitative measures of task relevance for different regions of interest (ROIs), the following ROIs were found to be the most contributing: the supramarginal and angular gyri of the inferior parietal lobule, the superior parietal lobule, the anterior part of the temporo-parietal junction connecting the superior temporal and supramarginal gyri, and the thalamus. MPA is likely to play an important role in elucidating the anatomical substrate of complex functions.
| Original language | English |
|---|---|
| Pages (from-to) | 3687-3695 |
| Number of pages | 9 |
| Journal | Human Brain Mapping |
| Volume | 30 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2009 |
Keywords
- Functional neuroanatomy
- Lesion method
- Localization of function
- Multiperturbation analysis
- Neuroimaging
- Spatial attention
- Unilateral spatial neglect
