TY - JOUR
T1 - Multiple interactions of unsaturated fatty acids with opiate and ouabain binding sites and βadrenergic sensitive adenylate cyclase system
AU - Xu, Heng
AU - Lichtstein, David
AU - Kassis, Shouki
AU - Lutz, Rudolf A.
AU - Rodbard, David
AU - Chernick, Sidney S.
PY - 1988
Y1 - 1988
N2 - The unsaturated fatty acids oleic, linoleic and arachidonic inhibited binding of ligands to the ouabain, opiate, and βadrenergic plasma membrane receptors. Low concentrations of fatty acids slightly increased the binding of ouabain to its binding sites. The effect of these fatty acids on βadrenergic sensitive adenylate cyclase was more complex. 0.2-0.3 mM fatty acids increased adenylate cyclase activity, while higher concentrations of arachidonic and linoleic acids, but not oleic acid
AB - The unsaturated fatty acids oleic, linoleic and arachidonic inhibited binding of ligands to the ouabain, opiate, and βadrenergic plasma membrane receptors. Low concentrations of fatty acids slightly increased the binding of ouabain to its binding sites. The effect of these fatty acids on βadrenergic sensitive adenylate cyclase was more complex. 0.2-0.3 mM fatty acids increased adenylate cyclase activity, while higher concentrations of arachidonic and linoleic acids, but not oleic acid
UR - http://www.scopus.com/inward/record.url?scp=0023887136&partnerID=8YFLogxK
U2 - 10.3109/10799898809048988
DO - 10.3109/10799898809048988
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C2 - 2838616
AN - SCOPUS:0023887136
SN - 1079-9893
VL - 8
SP - 205
EP - 223
JO - Journal of Receptor and Signal Transduction Research
JF - Journal of Receptor and Signal Transduction Research
IS - 1-4
ER -