Sensory systems encounter remarkably diverse stimuli in the external environment. Natural stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of adaptation, a ubiquitous feature of sensory systems, allow for the accommodation of this range of scales. Are there common rules of adaptation across different sensory modalities? We measured the membrane potential responses of individual neurons in the visual, somatosensory, and auditory cortices of male and female mice to discrete, punctate stimuli delivered at a wide range of fixed and nonfixed frequencies. We find that the adaptive profile of the response is largely preserved across these three areas, exhibiting attenuation and responses to the cessation of stimulation, which are signatures of response to changes in stimulus statistics. We demonstrate that these adaptive responses can emerge from a simple model based on the integration of fixed filters operating over multiple time scales.
Bibliographical noteFunding Information:
Received July 10, 2019; revised Oct. 1, 2019; accepted Oct. 1, 2019. Author contributions: K.W.L., D.B., M.S., I.N., I.L., A.L.F., and N.J.P. designed research; K.W.L., D.B., M.S., B.A., Y.K., I.N., I.L., A.L.F., and N.J.P. performed research; K.W.L., D.B., B.A., and N.J.P. analyzed data; K.W.L., D.B., A.L.F., and N.J.P. wrote the first draft of the paper; K.W.L., D.B., M.S., B.A., I.N., I.L., A.L.F., and N.J.P. edited the paper; K.W.L., D.B., I.N., I.L., A.L.F., and N.J.P. wrote the paper. This work was supported by the Human Frontiers Science Program to A.L.F., I.L., I.N. and N.J.P., and the Washington Research Foundation, University of Washington Institute of Neuroengineering to A.L.F. A.L.F. thanks Máté Lengyel for helpful discussions. The authors declare no competing financial interests. *K.W.L. and D.B. contributed equally to this work. †I.N., I.L., A.L.F., and N.J.P. contributed equally to this work as senior authors. Correspondence should be addressed to Nicholas J. Priebe at email@example.com. https://doi.org/10.1523/JNEUROSCI.1642-19.2019 Copyright © 2019 the authors
Copyright © 2019 the authors
- Auditory cortex
- Neural coding
- Somatosensory cortex
- Visual cortex