Murine B-cell leukemia lymphoma (BCL1) cells as a target for NK cell-mediated immunotherapy

L. Weiss; S. Reich; O. Mandelboim; S. Slavin

doi:10.1038/sj.bmt.1704475

Murine B-cell leukemia lymphoma (BCL1) cells as a target for NK cell-mediated immunotherapy

L. Weiss, S. Reich, O. Mandelboim, S. Slavin^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Natural killer (NK) cells are important for their ability to recognize and lyse tumor cells and virus infected cells. NK cells express triggering receptors that are specific for non-MHC ligands. This article describes the ³⁵S release cytotoxic assay, which measures the ability of NK cells derived from spleen cells taken from polyIC-treated mice to lyse B-cell leukemia (BCL1) cells. BCL1 cells express ligands for NKp46 on the cell surface membrane and they are sensitive to allogeneic but not syngeneic IL-2 activated natural killer cells.

Original language	American English
Pages (from-to)	1137-1141
Number of pages	5
Journal	Bone Marrow Transplantation
Volume	33
Issue number	11
DOIs	https://doi.org/10.1038/sj.bmt.1704475
State	Published - 1 Jun 2004

Bibliographical note

Funding Information:
We thank the Danny Cunniff Leukemia Research Laboratory; the Gabrielle Rich Leukemia Research Foundation; the Cancer Treatment Research Foundation; the Novotny Trust and the Fig Tree Foundation for their continuous support of our ongoing basic and clinical research.

Keywords

B-cell leukemia (BCL)
Immunity
Lymphokine activated killer cells (LAK cells)
Murine

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title = "Murine B-cell leukemia lymphoma (BCL1) cells as a target for NK cell-mediated immunotherapy",

abstract = "Natural killer (NK) cells are important for their ability to recognize and lyse tumor cells and virus infected cells. NK cells express triggering receptors that are specific for non-MHC ligands. This article describes the 35S release cytotoxic assay, which measures the ability of NK cells derived from spleen cells taken from polyIC-treated mice to lyse B-cell leukemia (BCL1) cells. BCL1 cells express ligands for NKp46 on the cell surface membrane and they are sensitive to allogeneic but not syngeneic IL-2 activated natural killer cells.",

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doi = "10.1038/sj.bmt.1704475",

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AU - Weiss, L.

AU - Reich, S.

AU - Mandelboim, O.

AU - Slavin, S.

N1 - Funding Information: We thank the Danny Cunniff Leukemia Research Laboratory; the Gabrielle Rich Leukemia Research Foundation; the Cancer Treatment Research Foundation; the Novotny Trust and the Fig Tree Foundation for their continuous support of our ongoing basic and clinical research.

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AB - Natural killer (NK) cells are important for their ability to recognize and lyse tumor cells and virus infected cells. NK cells express triggering receptors that are specific for non-MHC ligands. This article describes the 35S release cytotoxic assay, which measures the ability of NK cells derived from spleen cells taken from polyIC-treated mice to lyse B-cell leukemia (BCL1) cells. BCL1 cells express ligands for NKp46 on the cell surface membrane and they are sensitive to allogeneic but not syngeneic IL-2 activated natural killer cells.

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KW - Immunity

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Murine B-cell leukemia lymphoma (BCL1) cells as a target for NK cell-mediated immunotherapy

Abstract

Bibliographical note

Keywords

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