Muscarinic modulation of striatal function and circuitry

Joshua A. Goldberg, Jun B. Ding, D. James Surmeier*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

121 Scopus citations


Striatal cholinergic interneurons are pivotal modulators of the striatal circuitry involved in action selection and decision making. Although nicotinic receptors are important transducers of acetylcholine release in the striatum, muscarinic receptors are more pervasive and have been more thoroughly studied. In this review, the effects of muscarinic receptor signaling on the principal cell types in the striatum and its canonical circuits will be discussed, highlighting new insights into their role in synaptic integration and plasticity. These studies, and those that have identified new circuit elements driven by activation of nicotinic receptors, make it clear that temporally patterned activity in cholinergic interneurons must play an important role in determining the effects on striatal circuitry. These effects could be critical to the response to salient environmental stimuli that serve to direct behavior.

Original languageAmerican English
Title of host publicationMuscarinic Receptors
EditorsAllison D. Fryer, Neil M. Nathanson, Arthur Christopoulos
Number of pages19
StatePublished - 2012
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325


  • Acetylcholine
  • Autoreceptor
  • Cholinergic interneuron
  • Medium spiny projection neuron
  • Muscarinic receptor
  • Neuromodulation
  • Parkinson's disease
  • Striatum
  • Synaptic integration
  • Synaptic plasticity
  • Thalamus


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