Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

H. Özdaǧ; S. J. Batley; A. Försti; N. G. Iyer; Y. Daigo; J. Boutell; M. J. Arends; B. A.J. Ponder; T. Kouzarides; C. Caldas

doi:10.1038/sj.bjc.6600554

Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

H. Özdaǧ
, S. J. Batley
, A. Försti
, N. G. Iyer
, Y. Daigo
, J. Boutell
, M. J. Arends
, B. A.J. Ponder
, T. Kouzarides
, C. Caldas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

In this study we screened the histone acetyltransferases CBP and PCAF For mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers.

Original language	English
Pages (from-to)	1162-1165
Number of pages	4
Journal	British Journal of Cancer
Volume	87
Issue number	10
DOIs	https://doi.org/10.1038/sj.bjc.6600554
State	Published - 4 Nov 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CBP
Epithelial cancers
Mutations
P300
PCAF

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10.1038/sj.bjc.6600554

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title = "Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours",

abstract = "In this study we screened the histone acetyltransferases CBP and PCAF For mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers.",

keywords = "CBP, Epithelial cancers, Mutations, P300, PCAF",

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T1 - Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

AU - Özdaǧ, H.

AU - Batley, S. J.

AU - Försti, A.

AU - Iyer, N. G.

AU - Daigo, Y.

AU - Boutell, J.

AU - Arends, M. J.

AU - Ponder, B. A.J.

AU - Kouzarides, T.

AU - Caldas, C.

PY - 2002/11/4

Y1 - 2002/11/4

N2 - In this study we screened the histone acetyltransferases CBP and PCAF For mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers.

AB - In this study we screened the histone acetyltransferases CBP and PCAF For mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers.

KW - CBP

KW - Epithelial cancers

KW - Mutations

KW - P300

KW - PCAF

UR - https://www.scopus.com/pages/publications/18744391052

U2 - 10.1038/sj.bjc.6600554

DO - 10.1038/sj.bjc.6600554

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EP - 1165

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

Abstract

UN SDGs

Keywords

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