Abstract
Intracellular recordings were obtained from primary sensory neurons in excised dorsal root ganglia (DRGs). Most (90%) neurons sampled became depolarized during periods of repetitive stimulation of a branch of the dorsal root (DR) which contained only axons of neighboring neurons. DR stimulation also evoked a transient rise in extracellular K+ concentration ([K+]{ring operator}), following similar kinetics. Thus, the mutual excitati neurons may be mediated by [K+]{ring operator}. Activity-dependent cross-excitation in DRGs could contribute to neuropathic sensory abnormalities often triggered by nerve injury or disease.
Original language | English |
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Pages (from-to) | 53-56 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 146 |
Issue number | 1 |
DOIs | |
State | Published - 26 Oct 1992 |
Keywords
- Cross-excitation
- Dorsal root ganglion
- Extracellular potassium
- Pain
- Paresthesia