Mutual excitation among dorsal root ganglion neurons in the rat

David Utzschneider, Jeffery Kocsis, Marshall Devor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Intracellular recordings were obtained from primary sensory neurons in excised dorsal root ganglia (DRGs). Most (90%) neurons sampled became depolarized during periods of repetitive stimulation of a branch of the dorsal root (DR) which contained only axons of neighboring neurons. DR stimulation also evoked a transient rise in extracellular K+ concentration ([K+]{ring operator}), following similar kinetics. Thus, the mutual excitati neurons may be mediated by [K+]{ring operator}. Activity-dependent cross-excitation in DRGs could contribute to neuropathic sensory abnormalities often triggered by nerve injury or disease.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalNeuroscience Letters
Volume146
Issue number1
DOIs
StatePublished - 26 Oct 1992

Keywords

  • Cross-excitation
  • Dorsal root ganglion
  • Extracellular potassium
  • Pain
  • Paresthesia

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