Mycobacterium avium paratuberculosis invades human small-intestinal goblet cells and elicits inflammation

L. Golan, A. Livneh-Kol, E. Gonen, S. Yagel, I. Rosenshine, N. Y. Shpigel

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Crohn disease is a chronic inflammatory bowel disease of unknown etiology. Mycobacterium avium paratuberculosis (MAP) was found in the gut of patients with Crohn disease, but causality was not established. Fully developed, germ-free human small intestine and colon were established by subcutaneous transplantation of fetal gut into SCID (severe combined immunodeficiency) mice thereafter infected by direct intraluminal inoculation of MAP. We have found that MAP actively invades the human gut epithelial goblet cells of the small intestine, inducing severe tissue damage and inflammation. These observations indicate that MAP can specifically colonize the normal human small intestine and can elicit inflammation and severe mucosal damage.

Original languageAmerican English
Pages (from-to)350-354
Number of pages5
JournalJournal of Infectious Diseases
Volume199
Issue number3
DOIs
StatePublished - 1 Feb 2009

Bibliographical note

Funding Information:
Received 11 March 2008; accepted 22 May 2008; electronically published 10 January 2009. Potential conflicts of interest: none reported. Financial support: Binational Agricultural Research and Development Fund (IS-3413-03, IS-3673-05); Israel Science Foundation (F.I.R.S.T 256/06); Ministry of Health, State of Israel. Reprints or correspondence: Dr. N. Y. Shpigel, The Koret School of Veterinary Medicine, PO Box 12, Rehovot 76100, Israel (shpigeln@agri.huji.ac.il).

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