Mycoplasma fermentans (incognitus strain) induces TNFα and IL-1 production by human monocytes and murine macrophages

Ruth Gallily; Michael Salman; Mark Tarshis; Shlomo Rottem

doi:10.1016/0165-2478(92)90023-H

Mycoplasma fermentans (incognitus strain) induces TNFα and IL-1 production by human monocytes and murine macrophages

Ruth Gallily^*
, Michael Salman
, Mark Tarshis
, Shlomo Rottem

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We have demonstrated that Mycoplasma fermentans (incognitus strain), as well as M. fermentans KL4, PG 18 and IM 1 strains have the ability to activate human peripheral blood monocytes and murine macrophages of two inbred strains to secrete a high level of tumor necrosis factor α (TNFα) in a dose-dependent manner. Secretion of interleukin-1 (IL-1) was also stimulated following the incubation of human monocytes with the organism. We suggest that cytokine secretion following infection with M. fermentans (incognitus strain) that was detected in AIDS patients may contribute to the pathological manifestations, including cachexia, in this disease.

Original language	English
Pages (from-to)	27-30
Number of pages	4
Journal	Immunology Letters
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(92)90023-H
State	Published - Sep 1992

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytokine production, stimulation of
Macrophage
Monocyte
Mycoplasma fermentans

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10.1016/0165-2478(92)90023-H

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title = "Mycoplasma fermentans (incognitus strain) induces TNFα and IL-1 production by human monocytes and murine macrophages",

abstract = "We have demonstrated that Mycoplasma fermentans (incognitus strain), as well as M. fermentans KL4, PG 18 and IM 1 strains have the ability to activate human peripheral blood monocytes and murine macrophages of two inbred strains to secrete a high level of tumor necrosis factor α (TNFα) in a dose-dependent manner. Secretion of interleukin-1 (IL-1) was also stimulated following the incubation of human monocytes with the organism. We suggest that cytokine secretion following infection with M. fermentans (incognitus strain) that was detected in AIDS patients may contribute to the pathological manifestations, including cachexia, in this disease.",

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author = "Ruth Gallily and Michael Salman and Mark Tarshis and Shlomo Rottem",

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T1 - Mycoplasma fermentans (incognitus strain) induces TNFα and IL-1 production by human monocytes and murine macrophages

AU - Gallily, Ruth

AU - Salman, Michael

AU - Tarshis, Mark

AU - Rottem, Shlomo

PY - 1992/9

Y1 - 1992/9

N2 - We have demonstrated that Mycoplasma fermentans (incognitus strain), as well as M. fermentans KL4, PG 18 and IM 1 strains have the ability to activate human peripheral blood monocytes and murine macrophages of two inbred strains to secrete a high level of tumor necrosis factor α (TNFα) in a dose-dependent manner. Secretion of interleukin-1 (IL-1) was also stimulated following the incubation of human monocytes with the organism. We suggest that cytokine secretion following infection with M. fermentans (incognitus strain) that was detected in AIDS patients may contribute to the pathological manifestations, including cachexia, in this disease.

AB - We have demonstrated that Mycoplasma fermentans (incognitus strain), as well as M. fermentans KL4, PG 18 and IM 1 strains have the ability to activate human peripheral blood monocytes and murine macrophages of two inbred strains to secrete a high level of tumor necrosis factor α (TNFα) in a dose-dependent manner. Secretion of interleukin-1 (IL-1) was also stimulated following the incubation of human monocytes with the organism. We suggest that cytokine secretion following infection with M. fermentans (incognitus strain) that was detected in AIDS patients may contribute to the pathological manifestations, including cachexia, in this disease.

KW - Cytokine production, stimulation of

KW - Macrophage

KW - Monocyte

KW - Mycoplasma fermentans

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AN - SCOPUS:0026788523

SN - 0165-2478

VL - 34

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JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Mycoplasma fermentans (incognitus strain) induces TNFα and IL-1 production by human monocytes and murine macrophages

Abstract

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Keywords

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