NAD+-Dependent Deacetylases and Medical Therapy

A. Kumar*, L. Ben-Aderet, J. Elayyan, M. Dvir-Ginzberg

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Deacetylases are a class of enzymes which remove the ?-. N-acetyl groups from lysine amino acids in histone and nonhistone targets. There are four classes of HDACs, with a distinct subgroup called sirtuins (HDAC class III) that rely on nicotinamide adenine dinucleotide (NAD) for their catalytic activity. The fact that most of the sirtuins require NAD for their deacetylase activity, indicates that they are major energy-sensing proteins in cells and tissues with the potency to effect a plethora of biochemical, physiological, and pathological processes. These effects exerted by various sirtuins are discussed in this chapter, as well as the processes regulating NAD levels by de novo and salvage pathways. Finally, we elaborate on current agents targeting sirtuins and salvage pathway enzymes and their preclinical and clinical outcomes.

Original languageAmerican English
Title of host publicationMedical Epigenetics
PublisherElsevier Inc.
Pages657-684
Number of pages28
ISBN (Electronic)9780128032404
ISBN (Print)9780128032398
DOIs
StatePublished - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.

Keywords

  • NAMPT
  • NNMAT
  • Pathology
  • ROS
  • Resveratrol
  • SIRT1
  • SIRT1 activating compounds (STACs)
  • Salvage pathway
  • Sirtuin inhibitors and activators
  • Sirtuin signaling
  • Sirtuins

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