Nanocapsule formation by interfacial polymer deposition following solvent displacement

H. Fessi; F. Puisieux; J. Ph Devissaguet; N. Ammoury; S. Benita

doi:10.1016/0378-5173(89)90281-0

Nanocapsule formation by interfacial polymer deposition following solvent displacement

H. Fessi, F. Puisieux, J. Ph Devissaguet, N. Ammoury, S. Benita^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

2012 Scopus citations

Abstract

Indomethacin-loaded nanocapsules were prepared by deposition of poly-(D,L-lactide) polymer at the o/w interface following acetone displacement from the oily nanodroplets. An attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).

Original language	English
Pages (from-to)	R1-R4
Journal	International Journal of Pharmaceutics
Volume	55
Issue number	1
DOIs	https://doi.org/10.1016/0378-5173(89)90281-0
State	Published - 1 Oct 1989

Keywords

Indomethacin
Marangoni effect
Mechanism formation
Nanocapsule
Poly-(D,L-lactide) polymer

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10.1016/0378-5173(89)90281-0

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title = "Nanocapsule formation by interfacial polymer deposition following solvent displacement",

abstract = "Indomethacin-loaded nanocapsules were prepared by deposition of poly-(D,L-lactide) polymer at the o/w interface following acetone displacement from the oily nanodroplets. An attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).",

keywords = "Indomethacin, Marangoni effect, Mechanism formation, Nanocapsule, Poly-(D,L-lactide) polymer",

author = "H. Fessi and F. Puisieux and Devissaguet, {J. Ph} and N. Ammoury and S. Benita",

year = "1989",

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AU - Fessi, H.

AU - Puisieux, F.

AU - Devissaguet, J. Ph

AU - Ammoury, N.

AU - Benita, S.

PY - 1989/10/1

Y1 - 1989/10/1

N2 - Indomethacin-loaded nanocapsules were prepared by deposition of poly-(D,L-lactide) polymer at the o/w interface following acetone displacement from the oily nanodroplets. An attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).

AB - Indomethacin-loaded nanocapsules were prepared by deposition of poly-(D,L-lactide) polymer at the o/w interface following acetone displacement from the oily nanodroplets. An attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).

KW - Indomethacin

KW - Marangoni effect

KW - Mechanism formation

KW - Nanocapsule

KW - Poly-(D,L-lactide) polymer

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JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

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Nanocapsule formation by interfacial polymer deposition following solvent displacement

Abstract

Keywords

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