Nanoscale NMR spectroscopy and imaging of multiple nuclear species

Stephen J. Devience, Linh M. Pham, Igor Lovchinsky, Alexander O. Sushkov, Nir Bar-Gill, Chinmay Belthangady, Francesco Casola, Madeleine Corbett, Huiliang Zhang, Mikhail Lukin, Hongkun Park, Amir Yacoby, Ronald L. Walsworth*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

211 Scopus citations


Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) provide non-invasive information about multiple nuclear species in bulk matter, with wide-ranging applications from basic physics and chemistry to biomedical imaging. However, the spatial resolution of conventional NMR and MRI is limited to several micrometres even at large magnetic fields (>1T), which is inadequate for many frontier scientific applications such as single-molecule NMR spectroscopy and in vivo MRI of individual biological cells. A promising approach for nanoscale NMR and MRI exploits optical measurements of nitrogen-vacancy (NV) colour centres in diamond, which provide a combination of magnetic field sensitivity and nanoscale spatial resolution unmatched by any existing technology, while operating under ambient conditions in a robust, solid-state system. Recently, single, shallow NV centres were used to demonstrate NMR of nanoscale ensembles of proton spins, consisting of a statistical polarization equivalent to ∼100-1,000 spins in uniform samples covering the surface of a bulk diamond chip. Here, we realize nanoscale NMR spectroscopy and MRI of multiple nuclear species (1 H, 19 F, 31 P) in non-uniform (spatially structured) samples under ambient conditions and at moderate magnetic fields (∼20mT) using two complementary sensor modalities.

Original languageAmerican English
Pages (from-to)129-134
Number of pages6
JournalNature Nanotechnology
Issue number2
StatePublished - 1 Jan 2015

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