Abstract
We investigated the efficiency of nasal drug administration as a new non-invasive treatment strategy for MS. Glatiramer Acetate (GA) and GA-Cannabidiol (CBD) combination administered in nasal delivery system (NDS) resulted in a statistically significant decrease of clinical scores and inflammatory cytokine expression in experimental autoimmune encephalomyelitis (EAE) mice. Even a suboptimal dose of Prednisolone in NDS was effective in preventing the clinical signs of the disease. Neuron regeneration was observed in the hippocampus of EAE mice treated with GA-CBD in NDS. This work shows that nasal administration improved drug efficiency and stimulates further research for a non-invasive strategy for MS.
Original language | English |
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Pages (from-to) | 32-40 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 258 |
Issue number | 1-2 |
DOIs | |
State | Published - 2013 |
Keywords
- Cannabidiol
- Experimental autoimmune encephalomyelitis
- Glatiramer acetate
- Multiple sclerosis
- Nasal drug administration
- Neurogenesis