Nasopharyngeal carcinoma in children and young adults—Beyond 5-year survival

Tal Ben-Ami; Shifra Ash; Miri Ben-Harosh; Herzel Gavriel; Michael Weintraub; Shoshana Revel-Vilk; Myriam Ben-Arush

doi:10.1002/pbc.28494

Nasopharyngeal carcinoma in children and young adults—Beyond 5-year survival

Tal Ben-Ami^*
, Shifra Ash
, Miri Ben-Harosh
, Herzel Gavriel
, Michael Weintraub
, Shoshana Revel-Vilk
, Myriam Ben-Arush

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of NPC includes chemotherapy and radiotherapy. With current treatment protocols, survival rates for patients with nonmetastatic disease is over 80%. Data regarding very late events including long-term treatment-related morbidities and second malignancies are scarce. We present our data on 42 patients with NPC treated in Israel between 1989 and 2014, and followed until 2019. During follow up, five patients had disease recurrence, and four children developed secondary malignancy. Median time to diagnosis of secondary malignancy was 105 months. Eighty-eight percent of patients have long-term treatment-related morbidities.

Original language	English
Article number	e28494
Journal	Pediatric Blood and Cancer
Volume	67
Issue number	9
DOIs	https://doi.org/10.1002/pbc.28494
State	Published - 1 Sep 2020

Bibliographical note

Publisher Copyright:
© 2020 Wiley Periodicals LLC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

late toxicities
long-term follow up
nasopharyngeal carcinoma
second malignancies

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10.1002/pbc.28494

Cite this

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abstract = "Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of NPC includes chemotherapy and radiotherapy. With current treatment protocols, survival rates for patients with nonmetastatic disease is over 80\%. Data regarding very late events including long-term treatment-related morbidities and second malignancies are scarce. We present our data on 42 patients with NPC treated in Israel between 1989 and 2014, and followed until 2019. During follow up, five patients had disease recurrence, and four children developed secondary malignancy. Median time to diagnosis of secondary malignancy was 105 months. Eighty-eight percent of patients have long-term treatment-related morbidities.",

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AU - Ben-Ami, Tal

AU - Ash, Shifra

AU - Ben-Harosh, Miri

AU - Gavriel, Herzel

AU - Weintraub, Michael

AU - Revel-Vilk, Shoshana

AU - Ben-Arush, Myriam

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N2 - Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of NPC includes chemotherapy and radiotherapy. With current treatment protocols, survival rates for patients with nonmetastatic disease is over 80%. Data regarding very late events including long-term treatment-related morbidities and second malignancies are scarce. We present our data on 42 patients with NPC treated in Israel between 1989 and 2014, and followed until 2019. During follow up, five patients had disease recurrence, and four children developed secondary malignancy. Median time to diagnosis of secondary malignancy was 105 months. Eighty-eight percent of patients have long-term treatment-related morbidities.

AB - Nasopharyngeal carcinoma (NPC) is a rare and locally aggressive form of childhood cancer. Treatment of NPC includes chemotherapy and radiotherapy. With current treatment protocols, survival rates for patients with nonmetastatic disease is over 80%. Data regarding very late events including long-term treatment-related morbidities and second malignancies are scarce. We present our data on 42 patients with NPC treated in Israel between 1989 and 2014, and followed until 2019. During follow up, five patients had disease recurrence, and four children developed secondary malignancy. Median time to diagnosis of secondary malignancy was 105 months. Eighty-eight percent of patients have long-term treatment-related morbidities.

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KW - long-term follow up

KW - nasopharyngeal carcinoma

KW - second malignancies

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Nasopharyngeal carcinoma in children and young adults—Beyond 5-year survival

Abstract

Bibliographical note

UN SDGs

Keywords

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