TY - JOUR
T1 - Natural cell-mediated cytotoxicity in mice treated with total lymphoid irradiation (TLI)
AU - Weiss, Lola
AU - Kedar, Eli
AU - Weigensberg, Marilyn
AU - Slavin, Shimon
PY - 1982/6
Y1 - 1982/6
N2 - Fractionated total lymphoid irradiation (TLI) of adult (BALB/c × C57BL/6)F1 mice resulted in transiently augmented natural killer (NK) and natural cytotoxic (NC) cell activities. Thus, 1 day after completion of TLI, NK and NC activities in the spleens of treated mice were lower than controls but values increased and reached a maximum level of 23- to 190-fold above control at 6 days after irradiation, returning to normal levels 9 days later. Cytotoxicity was enhanced after removal of the plastic adherent population. No cytotoxicity was observed against P 815 target cells, which are sensitive to activated macrophages but not to NK. The significance of this modulation of natural cell-mediated cytotoxicity following TLI is discussed.
AB - Fractionated total lymphoid irradiation (TLI) of adult (BALB/c × C57BL/6)F1 mice resulted in transiently augmented natural killer (NK) and natural cytotoxic (NC) cell activities. Thus, 1 day after completion of TLI, NK and NC activities in the spleens of treated mice were lower than controls but values increased and reached a maximum level of 23- to 190-fold above control at 6 days after irradiation, returning to normal levels 9 days later. Cytotoxicity was enhanced after removal of the plastic adherent population. No cytotoxicity was observed against P 815 target cells, which are sensitive to activated macrophages but not to NK. The significance of this modulation of natural cell-mediated cytotoxicity following TLI is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0019959427&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(82)90144-7
DO - 10.1016/0008-8749(82)90144-7
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C2 - 7116463
AN - SCOPUS:0019959427
SN - 0008-8749
VL - 70
SP - 188
EP - 195
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1
ER -