TY - JOUR
T1 - Natural polysaccharides as targeting tools of drugs to the human colon
AU - Rubinstein, Abraham
PY - 2000
Y1 - 2000
N2 - The ability to deliver drugs to the human colon in a specific manner has become feasible in the last decade. A variety of means, including protective coats and pH-dependent polymers, are currently in use. Utilization of the metabolic activity of the colon is an attractive implement to improve the drug carriers' specificity. Biodegradable polymers, which are cleaved by colonic enzymes, can be used for that purpose. The mechanism of choice is azo-reduction and glycosidic-bond hydrolysis. In this review, some of the most common approaches to target drugs to the colon are reviewed and special attention is paid to modified polysaccharides as potential drug carriers to the human colon. (C) 2000 Wiley-Liss, Inc.
AB - The ability to deliver drugs to the human colon in a specific manner has become feasible in the last decade. A variety of means, including protective coats and pH-dependent polymers, are currently in use. Utilization of the metabolic activity of the colon is an attractive implement to improve the drug carriers' specificity. Biodegradable polymers, which are cleaved by colonic enzymes, can be used for that purpose. The mechanism of choice is azo-reduction and glycosidic-bond hydrolysis. In this review, some of the most common approaches to target drugs to the colon are reviewed and special attention is paid to modified polysaccharides as potential drug carriers to the human colon. (C) 2000 Wiley-Liss, Inc.
KW - Azo-reduction
KW - Biodegradable hydrogels
KW - Colon-specific drug delivery
KW - Colonic enzymes
KW - Crosslinking
KW - In vivo evaluation
KW - Natural polysaccharides
UR - http://www.scopus.com/inward/record.url?scp=0033819356&partnerID=8YFLogxK
U2 - 10.1002/1098-2299(200007/08)50:3/4<435::AID-DDR26>3.0.CO;2-5
DO - 10.1002/1098-2299(200007/08)50:3/4<435::AID-DDR26>3.0.CO;2-5
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:0033819356
SN - 0272-4391
VL - 50
SP - 435
EP - 439
JO - Drug Development Research
JF - Drug Development Research
IS - 3-4
ER -