TY - JOUR
T1 - NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation
AU - Miletic, Antonija
AU - Lenartic, Maja
AU - Popovic, Branka
AU - Brizic, Ilija
AU - Trsan, Tihana
AU - Miklic, Karmela
AU - Mandelboim, Ofer
AU - Krmpotic, Astrid
AU - Jonjic, Stipan
N1 - Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/9
Y1 - 2017/9
N2 - NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role in shaping the adaptive immune response to pathogens. Using NCR1-deficient (NCR1gfp/gfp) mice, we provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection (MCMV). The absence of NCR1 resulted in impaired maturation, function and NK-cell migration to regional lymph nodes. In addition, CD4+ T-cell activation and follicular helper T-cell (Tfh) generation were reduced, leading to inferior germinal center (GC) B-cell maturation. As a consequence, NCR1gfp/gfp mice produced lower amounts of MCMV-specific antibodies upon infection, which correlated with lower number of virus-specific antibody secreting cells in analyzed lymph nodes.
AB - NKp46/NCR1 is an activating NK-cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role in shaping the adaptive immune response to pathogens. Using NCR1-deficient (NCR1gfp/gfp) mice, we provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection (MCMV). The absence of NCR1 resulted in impaired maturation, function and NK-cell migration to regional lymph nodes. In addition, CD4+ T-cell activation and follicular helper T-cell (Tfh) generation were reduced, leading to inferior germinal center (GC) B-cell maturation. As a consequence, NCR1gfp/gfp mice produced lower amounts of MCMV-specific antibodies upon infection, which correlated with lower number of virus-specific antibody secreting cells in analyzed lymph nodes.
KW - Antiviral antibodies
KW - Follicular helper T cells
KW - Germinal center B cells
KW - NCR1 receptor
KW - NK-cell immunoregulation
KW - Viral infection
UR - http://www.scopus.com/inward/record.url?scp=85028913866&partnerID=8YFLogxK
U2 - 10.1002/eji.201646763
DO - 10.1002/eji.201646763
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C2 - 28643847
AN - SCOPUS:85028913866
SN - 0014-2980
VL - 47
SP - 1443
EP - 1456
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 9
ER -
