Necrosis in the Tumor Microenvironment and Its Role in Cancer Recurrence

Adi Karsch-Bluman, Ofra Benny*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

17 Scopus citations


Cancer recurrence is one of the most imminent problems in the current world of medicine, and it is responsible for most of the cancer-related death rates worldwide. Long-term administration of anticancer cytotoxic drugs may act as a double-edged sword, as necrosis may lead to renewed cancer progression and treatment resistance. The lack of nutrients, coupled with the induced hypoxia, triggers cell death and secretion of signals that affect the tumor niche. Many efforts have been made to better understand the contribution of hypoxia and metabolic stress to cancer progression and resistance, but mostly with respect to inflammation. Here we provide an overview of the direct anticancer effects of necrotic signals, which are not necessarily mediated by inflammation and the role of DAMPs (damage-associated molecular patterns) on the formation of a pro-cancerous environment.

Original languageAmerican English
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages10
StatePublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Publisher Copyright:
© 2020, Springer Nature Switzerland AG.


  • Angiogenesis
  • Anti-angiogenic therapy
  • Cancer
  • Chemotherapy
  • DAMPs
  • Hypoxia
  • Metabolic stress
  • Metronomic therapy
  • Necrosis
  • Recurrence
  • Resistance
  • Tumor microenvironment


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