NEET proteins belong to a newly discovered class of iron-sulfur proteins that harbor a unique labile [2Fe-2S] cluster and is thought to play a major role in preventing mitochondrial dysfunction. Mitochondrial dysfunction is associated with many human pathologies including diabetes, inflammation, neurodegeneration, and cancer. The degree of NEET [2Fe-2S] cluster stability was recently shown to affect mitochondrial function. Nevertheless, only a few compounds have thus far been discovered or designed as NEET ligands that control NEET [2Fe-2S] stability. This chapter summarizes the role of NEET proteins in different diseases and highlights the need to develop additional NEET ligands with a high therapeutic potential.
|Original language||American English|
|Title of host publication||Clinical Bioenergetics|
|Subtitle of host publication||From Pathophysiology to Clinical Translation|
|Number of pages||12|
|State||Published - 1 Jan 2020|
Bibliographical notePublisher Copyright:
© 2021 Elsevier Inc. All rights reserved.
- Cluster lability
- Drug design
- Iron-sulfur proteins
- Mitochondrial dysfunction
- NEET proteins