Abstract
NEET proteins belong to a newly discovered class of iron-sulfur proteins that harbor a unique labile [2Fe-2S] cluster and is thought to play a major role in preventing mitochondrial dysfunction. Mitochondrial dysfunction is associated with many human pathologies including diabetes, inflammation, neurodegeneration, and cancer. The degree of NEET [2Fe-2S] cluster stability was recently shown to affect mitochondrial function. Nevertheless, only a few compounds have thus far been discovered or designed as NEET ligands that control NEET [2Fe-2S] stability. This chapter summarizes the role of NEET proteins in different diseases and highlights the need to develop additional NEET ligands with a high therapeutic potential.
Original language | English |
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Title of host publication | Clinical Bioenergetics |
Subtitle of host publication | From Pathophysiology to Clinical Translation |
Publisher | Elsevier |
Pages | 477-488 |
Number of pages | 12 |
ISBN (Electronic) | 9780128196212 |
DOIs | |
State | Published - 1 Jan 2020 |
Bibliographical note
Publisher Copyright:© 2021 Elsevier Inc. All rights reserved.
Keywords
- Cluster lability
- Drug design
- Iron-sulfur proteins
- Mitochondrial dysfunction
- NEET proteins