Negative impact of 'old-to-old' donations on success of cadaveric renal transplants

Inbal Weiss-Salz, Micha Mandel, Noya Galai, Geoffrey Boner, Eytan Mor, Richard Nakache, Elisheva Simchen*, Tamar Ashkenazi, Ahmed Eid, Jonathan Halevi, Aaron Hoffman, Ron Loewenthal, Solly Mizrahi, Ruth Rahamimov, Anat Rotem, Moshe Shabtai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.

Original languageAmerican English
Pages (from-to)372-376
Number of pages5
JournalClinical Transplantation
Volume19
Issue number3
DOIs
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • 'Old-to-old' transplants
  • Cadaveric kidney transplant
  • Graft failure
  • Operative complications

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