TY - JOUR
T1 - Negative impact of 'old-to-old' donations on success of cadaveric renal transplants
AU - Weiss-Salz, Inbal
AU - Mandel, Micha
AU - Galai, Noya
AU - Boner, Geoffrey
AU - Mor, Eytan
AU - Nakache, Richard
AU - Simchen, Elisheva
AU - Ashkenazi, Tamar
AU - Eid, Ahmed
AU - Halevi, Jonathan
AU - Hoffman, Aaron
AU - Loewenthal, Ron
AU - Mizrahi, Solly
AU - Rahamimov, Ruth
AU - Rotem, Anat
AU - Shabtai, Moshe
PY - 2005/6
Y1 - 2005/6
N2 - The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.
AB - The effect of 'old-to-old' cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3-yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan-Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for 'old-to-old' transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). 'Old-to-old' transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. 'Old-to-old' transplants were also associated with increased operative complications relative to other age combinations. The decision to use 'old-to-old' transplants, even when donors are scarce, is problematic and should be reconsidered.
KW - 'Old-to-old' transplants
KW - Cadaveric kidney transplant
KW - Graft failure
KW - Operative complications
UR - https://www.scopus.com/pages/publications/21044439499
U2 - 10.1111/j.1399-0012.2005.00353.x
DO - 10.1111/j.1399-0012.2005.00353.x
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C2 - 15877801
AN - SCOPUS:21044439499
SN - 0902-0063
VL - 19
SP - 372
EP - 376
JO - Clinical Transplantation
JF - Clinical Transplantation
IS - 3
ER -