Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity

Biochemistry, Genetics and Molecular Biology

• WW Domain 100%
• Ubiquitin-Conjugating Enzyme 100%
• Carcinogenesis 100%
• Tumor Suppressor Protein 50%
• Cell Survival 50%
• Phosphotransferase 50%
• Kinase 50%
• Mesenchymal-Epithelial Transition 50%
• Mammalian Cell 50%
• Cell Fate 50%
• Cell Proliferation 50%
• Ubiquitination 50%
• Biological Phenomena and Functions Concerning the Entire Organism 50%
• Protein-Protein Interaction 50%
• Tyrosine 50%
• Cell Growth 50%
• Serine 50%
• Proline 50%
• Threonine 50%
• Drosophila 50%

Keyphrases

• Tumorigenicity 100%
• E3 Ubiquitin Ligase 100%
• Negative Regulation 100%
• Hippo Pathway 100%
• LATS1 100%
• WW Domain 28%
• Tumorigenesis 28%
• In Cancer 14%
• Tumor Suppressor Activity 14%
• Mammalian Cells 14%
• Cell Fate 14%
• Cell Proliferation 14%
• Ubiquitination 14%
• Protein-protein Interaction 14%
• Biological Processes 14%
• Proteasomal Degradation 14%
• Induced Apoptosis 14%
• Cellular Survival 14%
• Functional Links 14%
• Tyrosine 14%
• Proline 14%
• Cell Growth 14%
• Hippo 14%
• Epithelial-mesenchymal Transition 14%
• Serine-threonine Kinase 14%
• PPxY Motif 14%
• Growth Induction 14%

Immunology and Microbiology

• WW Domain 100%
• Cell Survival 50%
• Cell Proliferation 50%
• Cell Fate 50%
• Diptera 50%
• Ubiquitination 50%
• Biological Phenomena and Functions Concerning the Entire Organism 50%
• Cell Growth 50%
• Protein Protein Interaction 50%
• Epithelial Mesenchymal Transition 50%