Neighbor effects in the mutation of ochre triplets in the T4rII gene

Y. Salts; A. Ronen

doi:10.1016/0027-5107(71)90002-9

Neighbor effects in the mutation of ochre triplets in the T₄rII gene

Y. Salts^*
, A. Ronen

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

In 15 sites in the T₄rII gene, mutation from the ochre (UAA) codon to amber (UAG), opal (UGA) and the wild-type was measured with and without 2-aminopurine treatment. It is shown that a particular base pair in the DNA may show variable mutability, depending on its nearest neighbors. Also, similar base pairs at different sites in the gene can vary in their mutability despite the fact that they are flanked by similar neighbors.

Original language	English
Pages (from-to)	109-113
Number of pages	5
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0027-5107(71)90002-9
State	Published - Oct 1971

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abstract = "In 15 sites in the T4rII gene, mutation from the ochre (UAA) codon to amber (UAG), opal (UGA) and the wild-type was measured with and without 2-aminopurine treatment. It is shown that a particular base pair in the DNA may show variable mutability, depending on its nearest neighbors. Also, similar base pairs at different sites in the gene can vary in their mutability despite the fact that they are flanked by similar neighbors.",

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Neighbor effects in the mutation of ochre triplets in the T₄rII gene

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