Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes

Keyphrases

• AAV9 16%
• Ablation 16%
• Adeno-associated Viral Vector 16%
• Autosomal Recessive 33%
• Behavioral Deficits 16%
• Biallelic mutations 16%
• Central Nervous System 16%
• Clinical Outcomes 16%
• Complementary DNA (cDNA) 16%
• Encephalopathy Syndrome 16%
• Epileptic Encephalopathy 50%
• Gene Regulating 16%
• Gene Therapy 100%
• Germ Cells 16%
• Global Developmental Delay 16%
• Homeostasis 16%
• Hyperexcitability 16%
• Hypoglycemia 16%
• Hypomyelination 16%
• Intractable Epilepsy 16%
• Lethality 33%
• Myelination 16%
• Neural Genes 16%
• Neurodevelopmental Disorders 16%
• Neuronal Restoration 16%
• Null Mice 50%
• Null Phenotype 100%
• Seizure 16%
• Spinocerebellar Ataxia 33%
• Synapsin Promoter 16%
• WW Domain-containing Oxidoreductase 16%
• Wwox 100%
• WWOX Gene 100%

Neuroscience

• Adeno Associated Virus Vector 33%
• Adeno-Associated Virus 66%
• Brain Disease 100%
• Central Nervous System 33%
• Complementary DNA 33%
• Germ Cell 33%
• Hypoglycemia 33%
• Intractable Epilepsy 33%
• Myelinogenesis 33%
• Promoter Region 33%
• Spinocerebellar Ataxia 66%
• Synapsin I 33%
• WW Domain Containing Oxidoreductase 33%

Biochemistry, Genetics and Molecular Biology

• Adeno Associated Virus Vector 10%
• Autosomal Recessive Inheritance 20%
• Gene Therapy 100%
• Germ Cell 10%
• Germline 10%
• Homeostasis 10%
• Knockout Mouse 30%
• Myelination 10%
• Oxidoreductase 10%
• Promoter Region 10%
• Synapsin I 10%
• WW Domain 10%
• WWOX 100%