Nerve growth factor is produced by human fibroblasts and modulates them: Role of nerve growth factor in tissue repair

Some recent findings suggest the contribution of nerve growth factor (NGF) in tissue repair and fibrosis because of changed levels of this neurotrophin in these conditions that often follow an inflammatory insult. Data on the potential fibrogenicity of mast cells and eosinophils in fibrosis with different etiopathologies and in the one resulting from some allergic conditions are increasing. Both these cells produce NGF and their functions are modulated by this factor. However, the direct effects of NGF on fibroblasts, which represent the main effector and target cells of fibrosis, have been poorly investigated. This minireview reports on recent data concerning the involvement of NGF in allergic inflammation and in tissue repair/remodeling.