Neural generators of psychogenic seizures: Evidence from intracranial and extracranial brain recordings

Shahar Arzy; Pär Halje; Daniel S. Schechter; Laurent Spinelli; Margitta Seeck; Olaf Blanke

doi:10.1016/j.yebeh.2013.10.017

Neural generators of psychogenic seizures: Evidence from intracranial and extracranial brain recordings

Shahar Arzy^*, Pär Halje, Daniel S. Schechter, Laurent Spinelli, Margitta Seeck, Olaf Blanke

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Psychogenic seizures (PSs) convincingly mimic seizure phenomena but with no underlying epileptic activity. However, not much is known about their neurophysiological basis. We had the rare opportunity to analyze intracranial brain recordings of PSs occurring besides epileptic seizures (ESs), which identified distinct frequency changes over the parietal cortex. For further validation, we applied topographic frequency analysis to two other patients who presented PSs and ESs during long-term monitoring. The analysis revealed a power decrease in the theta band at the posterior parietal cortex in all three patients during PSs but not during ESs. These changes may reflect disturbed self-referential processing associated with some PSs.

Original language	English
Pages (from-to)	381-385
Number of pages	5
Journal	Epilepsy and Behavior
Volume	31
DOIs	https://doi.org/10.1016/j.yebeh.2013.10.017
State	Published - Feb 2014
Externally published	Yes

Bibliographical note

Funding Information:
We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Dr. Arzy was supported by the Marie Curie Intra-European Fellowship within the framework of the EU-FP7 program and the Ecole Polytechnique Fédérale de Lausanne (EPFL)–Hebrew University brain collaboration. Dr. Seeck is supported by SNF grant nos. 140332 and 140338 . Dr. Blanke was supported by The Swiss National Science Foundation and the Bertarelli Foundation.

Keywords

EEG
Frequency analysis
Intracranial recording
Psychogenic seizures
Theta rhythm

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title = "Neural generators of psychogenic seizures: Evidence from intracranial and extracranial brain recordings",

abstract = "Psychogenic seizures (PSs) convincingly mimic seizure phenomena but with no underlying epileptic activity. However, not much is known about their neurophysiological basis. We had the rare opportunity to analyze intracranial brain recordings of PSs occurring besides epileptic seizures (ESs), which identified distinct frequency changes over the parietal cortex. For further validation, we applied topographic frequency analysis to two other patients who presented PSs and ESs during long-term monitoring. The analysis revealed a power decrease in the theta band at the posterior parietal cortex in all three patients during PSs but not during ESs. These changes may reflect disturbed self-referential processing associated with some PSs.",

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note = "Funding Information: We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Dr. Arzy was supported by the Marie Curie Intra-European Fellowship within the framework of the EU-FP7 program and the Ecole Polytechnique F{\'e}d{\'e}rale de Lausanne (EPFL)–Hebrew University brain collaboration. Dr. Seeck is supported by SNF grant nos. 140332 and 140338 . Dr. Blanke was supported by The Swiss National Science Foundation and the Bertarelli Foundation. ",

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AU - Halje, Pär

AU - Schechter, Daniel S.

AU - Spinelli, Laurent

AU - Seeck, Margitta

AU - Blanke, Olaf

N1 - Funding Information: We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Dr. Arzy was supported by the Marie Curie Intra-European Fellowship within the framework of the EU-FP7 program and the Ecole Polytechnique Fédérale de Lausanne (EPFL)–Hebrew University brain collaboration. Dr. Seeck is supported by SNF grant nos. 140332 and 140338 . Dr. Blanke was supported by The Swiss National Science Foundation and the Bertarelli Foundation.

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N2 - Psychogenic seizures (PSs) convincingly mimic seizure phenomena but with no underlying epileptic activity. However, not much is known about their neurophysiological basis. We had the rare opportunity to analyze intracranial brain recordings of PSs occurring besides epileptic seizures (ESs), which identified distinct frequency changes over the parietal cortex. For further validation, we applied topographic frequency analysis to two other patients who presented PSs and ESs during long-term monitoring. The analysis revealed a power decrease in the theta band at the posterior parietal cortex in all three patients during PSs but not during ESs. These changes may reflect disturbed self-referential processing associated with some PSs.

AB - Psychogenic seizures (PSs) convincingly mimic seizure phenomena but with no underlying epileptic activity. However, not much is known about their neurophysiological basis. We had the rare opportunity to analyze intracranial brain recordings of PSs occurring besides epileptic seizures (ESs), which identified distinct frequency changes over the parietal cortex. For further validation, we applied topographic frequency analysis to two other patients who presented PSs and ESs during long-term monitoring. The analysis revealed a power decrease in the theta band at the posterior parietal cortex in all three patients during PSs but not during ESs. These changes may reflect disturbed self-referential processing associated with some PSs.

KW - EEG

KW - Frequency analysis

KW - Intracranial recording

KW - Psychogenic seizures

KW - Theta rhythm

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Neural generators of psychogenic seizures: Evidence from intracranial and extracranial brain recordings

Abstract

Bibliographical note

Keywords

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