Neural generators of psychogenic seizures: Evidence from intracranial and extracranial brain recordings

Shahar Arzy*, Pär Halje, Daniel S. Schechter, Laurent Spinelli, Margitta Seeck, Olaf Blanke

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Psychogenic seizures (PSs) convincingly mimic seizure phenomena but with no underlying epileptic activity. However, not much is known about their neurophysiological basis. We had the rare opportunity to analyze intracranial brain recordings of PSs occurring besides epileptic seizures (ESs), which identified distinct frequency changes over the parietal cortex. For further validation, we applied topographic frequency analysis to two other patients who presented PSs and ESs during long-term monitoring. The analysis revealed a power decrease in the theta band at the posterior parietal cortex in all three patients during PSs but not during ESs. These changes may reflect disturbed self-referential processing associated with some PSs.

Original languageAmerican English
Pages (from-to)381-385
Number of pages5
JournalEpilepsy and Behavior
Volume31
DOIs
StatePublished - Feb 2014
Externally publishedYes

Bibliographical note

Funding Information:
We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Dr. Arzy was supported by the Marie Curie Intra-European Fellowship within the framework of the EU-FP7 program and the Ecole Polytechnique Fédérale de Lausanne (EPFL)–Hebrew University brain collaboration. Dr. Seeck is supported by SNF grant nos. 140332 and 140338 . Dr. Blanke was supported by The Swiss National Science Foundation and the Bertarelli Foundation.

Keywords

  • EEG
  • Frequency analysis
  • Intracranial recording
  • Psychogenic seizures
  • Theta rhythm

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