TY - JOUR
T1 - NeurimmiRs
T2 - MicroRNAs in the neuroimmune interface
AU - Soreq, Hermona
AU - Wolf, Yochai
PY - 2011/10
Y1 - 2011/10
N2 - Recent reports of microRNA (miR) modulators of both neuronal and immune processes (here termed NeurimmiRs) predict therapeutic potential for manipulating NeurimmiR levels in diseases affecting both the immune system and higher brain functions, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS) and anxiety-related disorders. In our opinion, NeurimmiRs that function within both the nervous and the immune systems, such as miR-132 and miR-124, may act as 'negotiators' between these two interacting compartments. We suggest that NeurimmiRs primarily target transcriptional or other regulatory genes, which enables modulation of both immune and cognitive processes through direct or indirect alterations of neuron-glia and/or brain-to-body signaling. Thus, manipulating NeurimmiR control over the immune contributions to cognitive pathways may offer new therapeutic targets.
AB - Recent reports of microRNA (miR) modulators of both neuronal and immune processes (here termed NeurimmiRs) predict therapeutic potential for manipulating NeurimmiR levels in diseases affecting both the immune system and higher brain functions, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS) and anxiety-related disorders. In our opinion, NeurimmiRs that function within both the nervous and the immune systems, such as miR-132 and miR-124, may act as 'negotiators' between these two interacting compartments. We suggest that NeurimmiRs primarily target transcriptional or other regulatory genes, which enables modulation of both immune and cognitive processes through direct or indirect alterations of neuron-glia and/or brain-to-body signaling. Thus, manipulating NeurimmiR control over the immune contributions to cognitive pathways may offer new therapeutic targets.
UR - http://www.scopus.com/inward/record.url?scp=80053563273&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2011.06.009
DO - 10.1016/j.molmed.2011.06.009
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C2 - 21813326
AN - SCOPUS:80053563273
SN - 1471-4914
VL - 17
SP - 548
EP - 555
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 10
ER -
