TY - JOUR
T1 - Neurochemical mediators of the behavioural effects of receptor-selective substance P agonists administered intrathecally in the rat
AU - Papir-Kricheli, D.
AU - Gilon, C.
AU - Chorev, M.
AU - Selinger, Z.
AU - Devor, M.
PY - 1990/11
Y1 - 1990/11
N2 - Recently, two compounds have been developed, designated septide and senktide, which are highly selective agonists for the substance P receptor, types NK-1 and NK-3, respectively. Each of these, when injected intrathecally in awake rats, produced a distinct and non-overlapping constellation of sensory and behavioural effects which were subsets of the symptoms evoked by intrathecal administration of substance P. Prior systemic administration of 5-hydroxytryptamine (5-HT), α-adrenergic and opiate receptor antagonists, at doses sufficient to block the behavioural effects of the corresponding receptor agonists, did not alter responses to intrathecally injected septide or senktide. This was so, even for symptoms which suggested inhibitory mediation, hypoalgesia and (transient) motor flaccidity. Septide and senktide, administered by lumbar puncture and by indwelling catheter, produced identical results. Finally, in contrast to some other peptides, flaccid paralysis induced by senktide was not accompanied by spinal necrosis.
AB - Recently, two compounds have been developed, designated septide and senktide, which are highly selective agonists for the substance P receptor, types NK-1 and NK-3, respectively. Each of these, when injected intrathecally in awake rats, produced a distinct and non-overlapping constellation of sensory and behavioural effects which were subsets of the symptoms evoked by intrathecal administration of substance P. Prior systemic administration of 5-hydroxytryptamine (5-HT), α-adrenergic and opiate receptor antagonists, at doses sufficient to block the behavioural effects of the corresponding receptor agonists, did not alter responses to intrathecally injected septide or senktide. This was so, even for symptoms which suggested inhibitory mediation, hypoalgesia and (transient) motor flaccidity. Septide and senktide, administered by lumbar puncture and by indwelling catheter, produced identical results. Finally, in contrast to some other peptides, flaccid paralysis induced by senktide was not accompanied by spinal necrosis.
KW - analgesia
KW - intrathecal
KW - motor flaccidity
KW - pain
KW - senktide
KW - septide
KW - substance P
KW - tachykinins
UR - http://www.scopus.com/inward/record.url?scp=0025114655&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(90)90112-5
DO - 10.1016/0028-3908(90)90112-5
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C2 - 1708112
AN - SCOPUS:0025114655
SN - 0028-3908
VL - 29
SP - 1055
EP - 1065
JO - Neuropharmacology
JF - Neuropharmacology
IS - 11
ER -