TY - GEN
T1 - Neuroimaging distribution of water molecules in brain
AU - Vaganova, E.
AU - Yitzchaik, S.
AU - Ovadia, H.
AU - Borst, J. W.
AU - Visser, A.
AU - Sigalov, M.
AU - Khodorkovsky, V.
PY - 2006
Y1 - 2006
N2 - In the present work we introduce the novel method, which allow evaluate the quantitative distribution of water molecules in brain tissue. The method is based on the labeling of water molecules by two-photon chromophore and fluorescence lifetime imaging technique (FLIM) [1-3]. FLIM allows direct visualization of the spatially dependent fluorescence decay and it is not dependent on the chromophore concentration, excitation intensity, and light-path length. Three kinds of fluids are active in a brain: cerebrospinal, extracellular, and blood. The extracellular fluid compartment includes all water and electrolytes outside of cells (interstitial fluid, plasma, and lymph); cerebrospinal fluid (CSF) mostly contained water, and formed by ultrafiltration of blood in the choroid plexus (special cells that make up the walls of some collections of arteries) [4, 5].
AB - In the present work we introduce the novel method, which allow evaluate the quantitative distribution of water molecules in brain tissue. The method is based on the labeling of water molecules by two-photon chromophore and fluorescence lifetime imaging technique (FLIM) [1-3]. FLIM allows direct visualization of the spatially dependent fluorescence decay and it is not dependent on the chromophore concentration, excitation intensity, and light-path length. Three kinds of fluids are active in a brain: cerebrospinal, extracellular, and blood. The extracellular fluid compartment includes all water and electrolytes outside of cells (interstitial fluid, plasma, and lymph); cerebrospinal fluid (CSF) mostly contained water, and formed by ultrafiltration of blood in the choroid plexus (special cells that make up the walls of some collections of arteries) [4, 5].
KW - Brain tissue
KW - Fluorescence lifetime
KW - Imaging
KW - Two-photon chromophore
KW - Water
UR - http://www.scopus.com/inward/record.url?scp=33845214816&partnerID=8YFLogxK
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AN - SCOPUS:33845214816
SN - 0976798573
SN - 9780976798576
T3 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
SP - 470
EP - 472
BT - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
T2 - 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Y2 - 7 May 2006 through 11 May 2006
ER -