Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

J. Biederman; R. Rimon; R. Ebstein; J. Zohar; R. Belmaker

doi:10.1159/000117563

Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

J. Biederman
, R. Rimon
, R. Ebstein
, J. Zohar
, R. Belmaker

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

Original language	English
Pages (from-to)	324-327
Number of pages	4
Journal	Neuropsychobiology
Volume	2
Issue number	5-6
DOIs	https://doi.org/10.1159/000117563
State	Published - 1977
Externally published	Yes

Access to Document

10.1159/000117563

Cite this

@article{f85f7f9390f54cf482f147d4a9d598f3,

title = "Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients",

abstract = "Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.",

author = "J. Biederman and R. Rimon and R. Ebstein and J. Zohar and R. Belmaker",

year = "1977",

doi = "10.1159/000117563",

language = "אנגלית",

volume = "2",

pages = "324--327",

journal = "Neuropsychobiology",

issn = "0302-282X",

publisher = "S. Karger AG",

number = "5-6",

}

TY - JOUR

T1 - Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

AU - Biederman, J.

AU - Rimon, R.

AU - Ebstein, R.

AU - Zohar, J.

AU - Belmaker, R.

PY - 1977

Y1 - 1977

N2 - Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

AB - Cyclic AMP in the cerebrospinal fluid (CSF) was determined in a group of 10 schizophrenic patients before neuroleptic drug treatment and after a mean of 8 wk antipsychotic drug therapy. For 8 patients with marked to moderate treatment response a significant decline in CSF cyclic AMP was observed. This result is consistent with the theory that blockade of postsynaptic dopamine receptors is a major mechanism of the antipsychotic action of neuroleptic drugs.

UR - https://www.scopus.com/pages/publications/0017641419

U2 - 10.1159/000117563

DO - 10.1159/000117563

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 197445

AN - SCOPUS:0017641419

SN - 0302-282X

VL - 2

SP - 324

EP - 327

JO - Neuropsychobiology

JF - Neuropsychobiology

IS - 5-6

ER -

Neuroleptics reduce spinal fluid cyclic AMP in schizophrenic patients

Abstract

Access to Document

Other files and links

Fingerprint

Cite this