TY - JOUR
T1 - Neuropathic pain following partial nerve injury in rats is suppressed by dietary soy
AU - Shir, Yoram
AU - Ratner, Alexander
AU - Raja, Srinivasa N.
AU - Campbell, James N.
AU - Seltzer, Ze'ev
PY - 1998/1/9
Y1 - 1998/1/9
N2 - Some humans with partial nerve injury present a syndrome of neuropathic sensory disorders which depend on the sympathetic activity (sympathetically- maintained pain, SMP). Several years ago we introduced a rat model for SMP, produced by tightly ligating 1/3-1/2 of the sciatic nerve, leading to a partial denervation of the hindpaw (Partial Sciatic Ligation, PSL model) [Seltzer, Z., Dubner, R. and Shir, Y., Pain, 43 (1990) 245-250]. After working with this model for several years we encountered difficulties in replicating it although rat strain, vendor, gender, age and weight, surgical approach and sensory testing procedures were not changed. We report here that this variability can be attributed, at least in part, to the diet the animals consumed. Rats fed perioperatively with soy-containing diets expressed significantly weaker neuropathic sensory disorders compared to rats fed on soy-free diets. We conclude that diet may greatly affect experimental outcome in the PSL model.
AB - Some humans with partial nerve injury present a syndrome of neuropathic sensory disorders which depend on the sympathetic activity (sympathetically- maintained pain, SMP). Several years ago we introduced a rat model for SMP, produced by tightly ligating 1/3-1/2 of the sciatic nerve, leading to a partial denervation of the hindpaw (Partial Sciatic Ligation, PSL model) [Seltzer, Z., Dubner, R. and Shir, Y., Pain, 43 (1990) 245-250]. After working with this model for several years we encountered difficulties in replicating it although rat strain, vendor, gender, age and weight, surgical approach and sensory testing procedures were not changed. We report here that this variability can be attributed, at least in part, to the diet the animals consumed. Rats fed perioperatively with soy-containing diets expressed significantly weaker neuropathic sensory disorders compared to rats fed on soy-free diets. We conclude that diet may greatly affect experimental outcome in the PSL model.
KW - Allodynia
KW - Diet
KW - Hyperalgesia
KW - Neuropathic pain
KW - Pain modulation
KW - Partial nerve injury
KW - Phytoestrogens
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0032498194&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(97)00923-3
DO - 10.1016/S0304-3940(97)00923-3
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C2 - 9486475
AN - SCOPUS:0032498194
SN - 0304-3940
VL - 240
SP - 73
EP - 76
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -