Neuropathic Pain Models, CRPS-I Neuropathy Model

Complex regional pain syndrome (CRPS) is a neuropathic pain disorder that usually develops after a noxious event. Pain is frequently described as burning and continuous and exacerbated by movement, continuous stimulation, or stress. The syndrome includes spontaneous pain and/or stimulus evoked pain (allodynia and hyperalgesia), exceeding in both magnitude and duration the clinical course expected to follow the inciting event. Regardless of the site of injury, the symptoms begin and remain most intense in the distal extremity and are not limited to the distribution of a single peripheral nerve. At some point in time, pain may be associated with edema, changes in skin blood flow, and abnormal sudomotor activity in the same area, often resulting in significant impairment of motor function and showing variable progression over time. Two forms of CRPS have been identified.