Abstract
Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechano-allodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 1438-1440 |
| Number of pages | 3 |
| Journal | NeuroReport |
| Volume | 5 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jul 1994 |
Keywords
- Allodynia
- Dextrorphan
- Hyperalgesia
- NMDA antagonist
- Neuropathic pain