Neuropathic pain sensations are differentially sensitive to dextrorphan

M. Tal; G. J. Bennett

doi:10.1097/00001756-199407000-00008

Neuropathic pain sensations are differentially sensitive to dextrorphan

M. Tal
, G. J. Bennett^*

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechano-allodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.

Original language	English
Pages (from-to)	1438-1440
Number of pages	3
Journal	NeuroReport
Volume	5
Issue number	12
DOIs	https://doi.org/10.1097/00001756-199407000-00008
State	Published - Jul 1994

Keywords

Allodynia
Dextrorphan
Hyperalgesia
NMDA antagonist
Neuropathic pain

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title = "Neuropathic pain sensations are differentially sensitive to dextrorphan",

abstract = "Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechano-allodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.",

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AU - Bennett, G. J.

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N2 - Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechano-allodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.

AB - Rats with an experimental painful peripheral neuropathy (the CCI model) display heat-hyperalgesia and mechano-allodynia. Previous work has shown that the heat-hyperalgesia is suppressed by dextrorphan (DEX) and other N-methyl-D-aspartate (NMDA) receptor antagonists. The present work shows that when tested in the same rats, a dose of DEX that is maximally effective against heat-hyperalgesia has no effect on mechano-allodynia. The results suggest that different kinds of abnormal pain sensations may be caused by different pathophysiologic mechanisms that may respond differently to drug therapy.

KW - Allodynia

KW - Dextrorphan

KW - Hyperalgesia

KW - NMDA antagonist

KW - Neuropathic pain

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ER -

Neuropathic pain sensations are differentially sensitive to dextrorphan

Abstract

Keywords

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