Neurophotonic tools for microscopic measurements and manipulation: status report

Ahmed S. Abdelfattah, Sapna Ahuja, Taner Akkin, Srinivasa Rao Allu, Joshua Brake, David A. Boas, Erin M. Buckley, Robert E. Campbell, Anderson I. Chen, Xiaojun Cheng, Tom Ci m r, Irene Costantini, Massimo De Vittorio, Anna Devor*, Patrick R. Doran, Mirna El Khatib, Valentina Emiliani, Natalie Fomin-Thunemann, Yeshaiahu Fainman, Tomas Fernandez-AlfonsoChristopher G.L. Ferri, Ariel Gilad, Xue Han, Andrew Harris, Elizabeth M.C. Hillman, Ute Hochgeschwender, Matthew G. Holt, Na Ji, Klvllclm Klllç, Evelyn M.R. Lake, Lei Li, Tianqi Li, Philipp MäcHler, Evan W. Miller, Rickson C. Mesquita, K. M.Naga Srinivas Nadella, U. Valentin Nägerl, Yusuke Nasu, Axel Nimmerjahn, Petra Ondráčková, Francesco S. Pavone, Citlali Perez Campos, Darcy S. Peterka, Filippo Pisano, Ferruccio Pisanello, Francesca Puppo, Bernardo L. Sabatini, Sanaz Sadegh, Sava Sakadzic, Shy Shoham, Sanaya N. Shroff, R. Angus Silver, Ruth R. Sims, Spencer L. Smith, Vivek J. Srinivasan, Martin Thunemann, Lei Tian, Lin Tian, Thomas Troxler, Antoine Valera, Alipasha Vaziri, Sergei A. Vinogradov, Flavia Vitale, Lihong V. Wang, Hana Uhlírová, Chris Xu, Changhuei Yang, Mu Han Yang, Gary Yellen, Ofer Yizhar, Yongxin Zhao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics' agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions.

Original languageAmerican English
Pages (from-to)13001
Number of pages1
JournalNeurophotonics
Volume9
Issue numberS1
DOIs
StatePublished - 1 Jan 2022

Bibliographical note

Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Keywords

  • blood flow
  • fluorescence
  • label free
  • molecular sensors
  • multimodal
  • optical imaging
  • optogenetics

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