Neuropsychiatric Disorders and the Skeleton

Itai Bab*, Raz Yirmiya

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


It is now well established that some neuropsychiatric diseases, mainly major depressive disorder (MDD), anorexia nervosa (AN), and traumatic brain injury (TBI) are associated with changes in bone mass. Initial indications suggest that schizophrenia and Alzheimer's disease (AD) are accompanied by changes in bone density. A number of first-line agents used in the treatment of neuropsychiatric disorders are associated with low BMD and increased fracture risk, potentially amplifying the negative impact of these disorders on the skeleton. The most urgent unresolved clinical issue is the conflict between the beneficial effects of psychiatric medications, particularly in mood disorders and schizophrenia, and the deleterious effects of the very same medications on the skeleton.

Original languageAmerican English
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Subtitle of host publicationEighth Edition
Number of pages10
ISBN (Electronic)9781118453926
ISBN (Print)9781118453889
StatePublished - 19 Jul 2013

Bibliographical note

Publisher Copyright:
© 2013 American Society for Bone and Mineral Research. All rights reserved.


  • Alzheimer's disease
  • Anorexia nervosa (AN)
  • Major depressive disorder (MDD)
  • Neuropsychiatrie disorders
  • Schizophrenia
  • Skeleton
  • Traumatic brain injury (TBI)


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