Neutrophil Diversity in Health and Disease

Carlos Silvestre-Roig; Zvi G. Fridlender; Michael Glogauer; Patrizia Scapini

doi:10.1016/j.it.2019.04.012

Neutrophil Diversity in Health and Disease

Carlos Silvestre-Roig, Zvi G. Fridlender, Michael Glogauer, Patrizia Scapini^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

244 Scopus citations

Abstract

New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.

Original language	American English
Pages (from-to)	565-583
Number of pages	19
Journal	Trends in Immunology
Volume	40
Issue number	7
DOIs	https://doi.org/10.1016/j.it.2019.04.012
State	Published - Jul 2019
Externally published	Yes

Bibliographical note

Funding Information:
We thank M.A. Cassatella for critical suggestions and helpful comments. This work was supported by grants from the Deutsche Forschungsgemeinschaft (DGF; grant SFB1123 TP A6 ) and the Else Kröner-Fresenius-Stiftung (EKFS, 2016_A118 ) (to C.S.R); the Israeli Cancer Research Foundation ( 01229/17 ) and the Israel Science Foundation ( 2122/16 ) (to Z.G.F); the Canadian Institutes of Health Research (to M.G.); the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG20339 ) and Fondazione Cariverona (to P.S.). This work was also supported by European Cooperation in Science and Technology (COST) Action BM1404 Mye-EUNITER ( www.mye-euniter.eu ); COST is supported by the EU Framework Program Horizon 2020.

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

immune regulation
neutrophils
subpopulations

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10.1016/j.it.2019.04.012

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title = "Neutrophil Diversity in Health and Disease",

abstract = "New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.",

keywords = "immune regulation, neutrophils, subpopulations",

author = "Carlos Silvestre-Roig and Fridlender, {Zvi G.} and Michael Glogauer and Patrizia Scapini",

note = "Funding Information: We thank M.A. Cassatella for critical suggestions and helpful comments. This work was supported by grants from the Deutsche Forschungsgemeinschaft (DGF; grant SFB1123 TP A6 ) and the Else Kr{\"o}ner-Fresenius-Stiftung (EKFS, 2016_A118 ) (to C.S.R); the Israeli Cancer Research Foundation ( 01229/17 ) and the Israel Science Foundation ( 2122/16 ) (to Z.G.F); the Canadian Institutes of Health Research (to M.G.); the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG20339 ) and Fondazione Cariverona (to P.S.). This work was also supported by European Cooperation in Science and Technology (COST) Action BM1404 Mye-EUNITER ( www.mye-euniter.eu ); COST is supported by the EU Framework Program Horizon 2020. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

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AU - Fridlender, Zvi G.

AU - Glogauer, Michael

AU - Scapini, Patrizia

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N2 - New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.

AB - New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.

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Neutrophil Diversity in Health and Disease

Abstract

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