Neutrophil Diversity in Health and Disease

Carlos Silvestre-Roig, Zvi G. Fridlender, Michael Glogauer, Patrizia Scapini*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

300 Scopus citations

Abstract

New evidence has challenged the outdated dogma that neutrophils are a homogeneous population of short-lived cells. Although neutrophil subpopulations with distinct functions have been reported under homeostatic and pathological conditions, a full understanding of neutrophil heterogeneity and plasticity is currently lacking. We review here current knowledge of neutrophil heterogeneity and diversity, highlighting the need for deep genomic, phenotypic, and functional profiling of the identified neutrophil subpopulations to determine whether these cells truly represent bona fide novel neutrophil subsets. We suggest that progress in understanding neutrophil heterogeneity will allow the identification of clinically relevant neutrophil subpopulations that may be used in the diagnosis of specific diseases and lead to the development of new therapeutic approaches.

Original languageAmerican English
Pages (from-to)565-583
Number of pages19
JournalTrends in Immunology
Volume40
Issue number7
DOIs
StatePublished - Jul 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

  • immune regulation
  • neutrophils
  • subpopulations

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