Neutrophil phenotypes and functions in cancer: A consensus statement

Daniela F. Quail*, Borko Amulic, Monowar Aziz, Betsy J. Barnes, Evgeniy Eruslanov, Zvi G. Fridlender, Helen S. Goodridge, Zvi Granot, Andrés Hidalgo, Anna Huttenlocher, Mariana J. Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikael J. Pittet, Andrea Rubio-Ponce, Irina A. Udalova, Timo K. van den Berg, Denisa D. WagnerPing Wang, Arturo Zychlinsky, Karin E. de Visser, Mikala Egeblad, Paul Kubes

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.

Original languageAmerican English
Article numbere20220011
JournalJournal of Experimental Medicine
Volume219
Issue number6
DOIs
StatePublished - 6 Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 Quail et al.

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