New anti-inflammatory mechanism of glucocorticoids uncovered

Carolyn L. Cummins; Ido Goldstein

doi:10.1016/j.tem.2024.08.003

New anti-inflammatory mechanism of glucocorticoids uncovered

Carolyn L. Cummins^*, Ido Goldstein

^*Corresponding author for this work

Institute of Biochemistry, Food Science and Nutrition

Research output: Contribution to journal › Short survey › peer-review

Abstract

Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

Original language	English
Journal	Trends in Endocrinology and Metabolism
DOIs	https://doi.org/10.1016/j.tem.2024.08.003
State	Accepted/In press - 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

Keywords

GR
LPS
PDH
itaconate
macrophage

Access to Document

10.1016/j.tem.2024.08.003

Cite this

@article{4261bca421794f2f8bd662bab7ae6207,

title = "New anti-inflammatory mechanism of glucocorticoids uncovered",

abstract = "Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.",

keywords = "GR, LPS, PDH, itaconate, macrophage",

author = "Cummins, {Carolyn L.} and Ido Goldstein",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

doi = "10.1016/j.tem.2024.08.003",

language = "אנגלית",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - New anti-inflammatory mechanism of glucocorticoids uncovered

AU - Cummins, Carolyn L.

AU - Goldstein, Ido

PY - 2024

Y1 - 2024

N2 - Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

AB - Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.

KW - GR

KW - LPS

KW - PDH

KW - itaconate

KW - macrophage

UR - http://www.scopus.com/inward/record.url?scp=85202457302&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2024.08.003

DO - 10.1016/j.tem.2024.08.003

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.shortsurvey???

C2 - 39181729

AN - SCOPUS:85202457302

SN - 1043-2760

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

ER -

New anti-inflammatory mechanism of glucocorticoids uncovered

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this