New backbone cyclic substance P analogs

Gal Bitan; Stephan Behrens; Barbara Mathä; Yaffa Mashriki; Menachem Hanani; Horst Kessler; Chaim Gilon

doi:10.1007/BF00119137

New backbone cyclic substance P analogs

Gal Bitan^*, Stephan Behrens, Barbara Mathä, Yaffa Mashriki, Menachem Hanani, Horst Kessler, Chaim Gilon

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Structure-activity relationships of cyclic substance P (SP) analogs were extensively studied in our laboratories utilizing the new concept of backbone cyclization. Employing the C-terminal hexapeptide SP_6-11, we examined the influence of chemical changes in peptides containing backbone-to-amino-end cyclization. These changes in the ring have significant influence on activity, and should be carefully designed in order to optimize pharmacological feature.

Original language	English
Pages (from-to)	121-124
Number of pages	4
Journal	Letters in Peptide Science
Volume	2
Issue number	3-4
DOIs	https://doi.org/10.1007/BF00119137
State	Published - Nov 1995

Keywords

Backbone cyclization
Conformational analysis
Molecular dynamics
NMR
Substance P

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10.1007/BF00119137

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title = "New backbone cyclic substance P analogs",

abstract = "Structure-activity relationships of cyclic substance P (SP) analogs were extensively studied in our laboratories utilizing the new concept of backbone cyclization. Employing the C-terminal hexapeptide SP6-11, we examined the influence of chemical changes in peptides containing backbone-to-amino-end cyclization. These changes in the ring have significant influence on activity, and should be carefully designed in order to optimize pharmacological feature.",

keywords = "Backbone cyclization, Conformational analysis, Molecular dynamics, NMR, Substance P",

author = "Gal Bitan and Stephan Behrens and Barbara Math{\"a} and Yaffa Mashriki and Menachem Hanani and Horst Kessler and Chaim Gilon",

year = "1995",

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AU - Bitan, Gal

AU - Behrens, Stephan

AU - Mathä, Barbara

AU - Mashriki, Yaffa

AU - Hanani, Menachem

AU - Kessler, Horst

AU - Gilon, Chaim

PY - 1995/11

Y1 - 1995/11

N2 - Structure-activity relationships of cyclic substance P (SP) analogs were extensively studied in our laboratories utilizing the new concept of backbone cyclization. Employing the C-terminal hexapeptide SP6-11, we examined the influence of chemical changes in peptides containing backbone-to-amino-end cyclization. These changes in the ring have significant influence on activity, and should be carefully designed in order to optimize pharmacological feature.

AB - Structure-activity relationships of cyclic substance P (SP) analogs were extensively studied in our laboratories utilizing the new concept of backbone cyclization. Employing the C-terminal hexapeptide SP6-11, we examined the influence of chemical changes in peptides containing backbone-to-amino-end cyclization. These changes in the ring have significant influence on activity, and should be carefully designed in order to optimize pharmacological feature.

KW - Backbone cyclization

KW - Conformational analysis

KW - Molecular dynamics

KW - NMR

KW - Substance P

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JO - Letters in Peptide Science

JF - Letters in Peptide Science

IS - 3-4

ER -

New backbone cyclic substance P analogs

Abstract

Keywords

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