TY - JOUR
T1 - New cannabidiol derivatives
T2 - Synthesis, binding to cannabinoid receptor, and evaluation of their antiinflammatory activity
AU - Ben-Shabat, Shimon
AU - Hanuš, Lumír O.
AU - Katzavian, Galia
AU - Gallily, Ruth
PY - 2006/2/9
Y1 - 2006/2/9
N2 - Cannabidiol (CBD) and cannabidiol dimethyl hephtyl (CBD-DMH) were hydrogenated to give four different epimers. The new derivatives were evaluated for their ability to modulate the production of reactive oxygen intermediates (ROI), nitric oxide (NO), and tumor necrosis factor (TNF-α) by murine macrophages, and for their binding to the cannabinoid receptor (CB1). Surprisingly, we found that these derivatives exhibit good binding to CB 1. In addition hydrogenated CBD and CBD-DMH demonstrate bioactivities different from their original compounds.
AB - Cannabidiol (CBD) and cannabidiol dimethyl hephtyl (CBD-DMH) were hydrogenated to give four different epimers. The new derivatives were evaluated for their ability to modulate the production of reactive oxygen intermediates (ROI), nitric oxide (NO), and tumor necrosis factor (TNF-α) by murine macrophages, and for their binding to the cannabinoid receptor (CB1). Surprisingly, we found that these derivatives exhibit good binding to CB 1. In addition hydrogenated CBD and CBD-DMH demonstrate bioactivities different from their original compounds.
UR - http://www.scopus.com/inward/record.url?scp=32344437376&partnerID=8YFLogxK
U2 - 10.1021/jm050709m
DO - 10.1021/jm050709m
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C2 - 16451075
AN - SCOPUS:32344437376
SN - 0022-2623
VL - 49
SP - 1113
EP - 1117
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 3
ER -
