TY - JOUR
T1 - New gadget in the membrane trafficking toolbox
T2 - A novel inhibitor of SNARE priming
AU - Abeliovich, Hagai
N1 - Publisher Copyright:
© 2019 Abeliovich.
PY - 2019/11/15
Y1 - 2019/11/15
N2 - NSF (N-ethylmaleimide sensitive factor) and its yeast counterpart Sec18 are highly conserved homohexameric proteins that play vital roles in eukaryotic membrane trafficking. Sec18 functions by disrupting SNARE complexes formed in cis, on the same membrane. However, the molecular mechanisms of this process are poorly understood, in large part due to the lack of selective, reversible inhibitors. A new study by Sparks et al. now reports a small molecule that appears to selectively inhibit Sec18 action in an in vitro assay. Their finding now paves the way to elucidate further details of Sec18-mediated SNARE priming.
AB - NSF (N-ethylmaleimide sensitive factor) and its yeast counterpart Sec18 are highly conserved homohexameric proteins that play vital roles in eukaryotic membrane trafficking. Sec18 functions by disrupting SNARE complexes formed in cis, on the same membrane. However, the molecular mechanisms of this process are poorly understood, in large part due to the lack of selective, reversible inhibitors. A new study by Sparks et al. now reports a small molecule that appears to selectively inhibit Sec18 action in an in vitro assay. Their finding now paves the way to elucidate further details of Sec18-mediated SNARE priming.
UR - http://www.scopus.com/inward/record.url?scp=85075113063&partnerID=8YFLogxK
U2 - 10.1074/jbc.H119.011334
DO - 10.1074/jbc.H119.011334
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C2 - 31732684
AN - SCOPUS:85075113063
SN - 0021-9258
VL - 294
SP - 17186
EP - 17187
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 46
ER -