TY - JOUR
T1 - New insights on the involvement of Nerve Growth Factor in allergic inflammation and fibrosis
AU - Micera, Alessandra
AU - Puxeddu, Ilaria
AU - Aloe, Luigi
AU - Levi-Schaffer, Francesca
PY - 2003/10
Y1 - 2003/10
N2 - Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influenced by it. These observations have prompted studies on NGF in allergy and tissue repair. Recent evidences link NGF and these two processes. While NGF is clearly a new tool in the management of untreatable ulcers, its role in allergic inflammation, although appearing to be pro-inflammatory, is still not clearly defined.
AB - Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influenced by it. These observations have prompted studies on NGF in allergy and tissue repair. Recent evidences link NGF and these two processes. While NGF is clearly a new tool in the management of untreatable ulcers, its role in allergic inflammation, although appearing to be pro-inflammatory, is still not clearly defined.
KW - Allergy
KW - Eosinophils
KW - Fibrosis
KW - Inflammation
KW - Mast cells
KW - Myofibroblasts
KW - NGF
UR - http://www.scopus.com/inward/record.url?scp=0042375985&partnerID=8YFLogxK
U2 - 10.1016/S1359-6101(03)00047-9
DO - 10.1016/S1359-6101(03)00047-9
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C2 - 12948520
AN - SCOPUS:0042375985
SN - 1359-6101
VL - 14
SP - 369
EP - 374
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 5
ER -