New reduction pathways for ctc-[PtCl2(CH3CO 2)2(NH3)(Am)] anticancer prodrugs

Alina Nemirovski; Inbal Vinograd; Khuloud Takrouri; Ana Mijovilovich; Annette Rompel; Dan Gibson

doi:10.1039/b925721g

New reduction pathways for ctc-[PtCl₂(CH₃CO ₂)₂(NH₃)(Am)] anticancer prodrugs

Alina Nemirovski
, Inbal Vinograd
, Khuloud Takrouri
, Ana Mijovilovich
, Annette Rompel
, Dan Gibson^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Reduction of anticancer prodrugs such as ctc-[PtCl2(CH3CO2)2(NH3)(Am)] can yield three products in addition to the expected cis-[PtCl2(NH3)(Am)]. A possible explanation is that reduction proceeds by several pathways where in addition to the loss of two axial ligands, one axial (acetato) and one equatorial (chlorido) ligand, or two equatorial ligands are eliminated.

Original language	English
Pages (from-to)	1842-1844
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	11
DOIs	https://doi.org/10.1039/b925721g
State	Published - 2010

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abstract = "Reduction of anticancer prodrugs such as ctc-[PtCl2(CH3CO2)2(NH3)(Am)] can yield three products in addition to the expected cis-[PtCl2(NH3)(Am)]. A possible explanation is that reduction proceeds by several pathways where in addition to the loss of two axial ligands, one axial (acetato) and one equatorial (chlorido) ligand, or two equatorial ligands are eliminated.",

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AU - Nemirovski, Alina

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AU - Takrouri, Khuloud

AU - Mijovilovich, Ana

AU - Rompel, Annette

AU - Gibson, Dan

PY - 2010

Y1 - 2010

N2 - Reduction of anticancer prodrugs such as ctc-[PtCl2(CH3CO2)2(NH3)(Am)] can yield three products in addition to the expected cis-[PtCl2(NH3)(Am)]. A possible explanation is that reduction proceeds by several pathways where in addition to the loss of two axial ligands, one axial (acetato) and one equatorial (chlorido) ligand, or two equatorial ligands are eliminated.

AB - Reduction of anticancer prodrugs such as ctc-[PtCl2(CH3CO2)2(NH3)(Am)] can yield three products in addition to the expected cis-[PtCl2(NH3)(Am)]. A possible explanation is that reduction proceeds by several pathways where in addition to the loss of two axial ligands, one axial (acetato) and one equatorial (chlorido) ligand, or two equatorial ligands are eliminated.

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New reduction pathways for ctc-[PtCl₂(CH₃CO ₂)₂(NH₃)(Am)] anticancer prodrugs

Abstract

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