TY - JOUR
T1 - Nimodipine counteracts corticosterone-induced habituation impairments
AU - Dachir, Shlomit
AU - Robinzon, Boaz
AU - Grauer, Ettie
AU - Levy, Aharon
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Corticosterone or placebo sustained-release pellets (4 pellets of 200 mg each, released over 90 days) were implanted subcutaneously in young Fischer- 344 rats, fed with either regular food or with food containing 860 ppm of nimodipine. Following 2 weeks of treatment, the habituation of the rats to a new environment was studied. On the first test day, placebo-implanted rats explored the new environment and exhibited a characteristic habituation. On the second test day, 48 hr later, low activity was measured in the already familiar environment. This habituation was absent in corticosterone-implanted rats fed with regular food. However, corticosterone-implanted rats fed with food containing nimodipine behaved during the second test similarly to the placebo-implanted group. The data indicated that the behavioral deficit, induced in Fischer-344 rats by the high corticosterone levels, was reversed by the nimodipine treatment. Thus, nimodipine may be useful in counteracting certain prolonged stress-related cognitive impairments.
AB - Corticosterone or placebo sustained-release pellets (4 pellets of 200 mg each, released over 90 days) were implanted subcutaneously in young Fischer- 344 rats, fed with either regular food or with food containing 860 ppm of nimodipine. Following 2 weeks of treatment, the habituation of the rats to a new environment was studied. On the first test day, placebo-implanted rats explored the new environment and exhibited a characteristic habituation. On the second test day, 48 hr later, low activity was measured in the already familiar environment. This habituation was absent in corticosterone-implanted rats fed with regular food. However, corticosterone-implanted rats fed with food containing nimodipine behaved during the second test similarly to the placebo-implanted group. The data indicated that the behavioral deficit, induced in Fischer-344 rats by the high corticosterone levels, was reversed by the nimodipine treatment. Thus, nimodipine may be useful in counteracting certain prolonged stress-related cognitive impairments.
UR - http://www.scopus.com/inward/record.url?scp=0029023666&partnerID=8YFLogxK
U2 - 10.1006/nlme.1995.1028
DO - 10.1006/nlme.1995.1028
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AN - SCOPUS:0029023666
SN - 1074-7427
VL - 63
SP - 241
EP - 245
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
IS - 3
ER -