NKp46

Ofer Mandelboim*, Angel Porgador

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Combating diseases such as cancer and virus infection is one of the major goals of the next millennium. Remarkably, our immune system has developed a unique cell type called Natural Killer (NK) cells, able to kill cancer and virus-infected cells. The nature of the lysis/killer receptors expressed on NK cells, mediating this killing, and their ligands, is only little understood. Four lysis receptors for human NK cells were recently identified, including the NKp30, NKp44, NKp46 and CD16, all of which are capable of mediating direct killing of virus-infected and tumor cells. Among these, the NKp46 receptor is considered to be the major lysis receptor for NK cells. The viral hemagglutinin protein was recently identified as the ligand for the NKp46 receptor. However, the cellular (non-viral) ligands recognized by all of the lysis receptors (NKp30, NKp44, NKp46 and CD16) are currently unknown.

Original languageAmerican English
Pages (from-to)1147-1150
Number of pages4
JournalInternational Journal of Biochemistry and Cell Biology
Volume33
Issue number12
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
O.M. and A.P. are supported by research grants from the Israel Cancer Research Foundation and USA–Israel Binational Science Foundation. O.M. is also supported by research grants from the Israel Science Foundation, The Charles H. Revson Foundation (No. 153/00) and from the joint German–Israeli Research programs.

Keywords

  • Lysis
  • NK cells
  • NKp46

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