NMR characterization of a Cu(i)-bound peptide model of copper metallochaperones: Insights on the role of methionine

Michal S. Shoshan, Deborah E. Shalev, Wencke Adriaens, Maarten Merkx, Tilman M. Hackeng, Edit Y. Tshuva

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The first NMR structure of a Cu(i)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ∼3.0 and ∼6.8 Cu(i) binds through one Cys and the Met rather than the two Cys residues, differently than at pH ∼8.5. This suggests a possible role of Met in metal transport.

Original languageAmerican English
Pages (from-to)6407-6409
Number of pages3
JournalChemical Communications
Volume47
Issue number22
DOIs
StatePublished - 14 Jun 2011

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