No sympathetic nerve sprouting in rat trigeminal ganglion following painful and non-painful infraorbital nerve neuropathy

Rafael Benoliel*, Eli Eliav, Michael Tal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Following sciatic nerve injury sympathetic invasion and basket formation is seen in dorsal root ganglia. We examined whether this phenomenon occurs in trigeminal ganglion (TG) following axotomy (IOAx) or chronic constriction injury to the infraorbital nerve (IOCCI). The IOCCI rats developed hyperresponsiveness to pinprick stimulation consistent with this model and the IOAx rats remained hyporesponsive for most of the study period. Immunocytochemistry employing antibodies to tyrosine hydroxylase showed no sympathetic invasion or basket formation 2 and 7 weeks post surgery. This study confirms previous work that found no sympathetic invasion of TG following injury, and shows that this finding is unaffected by the presence or absence of nerve injury induced hyperresponsiveness.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalNeuroscience Letters
Volume297
Issue number3
DOIs
StatePublished - 19 Jan 2001

Keywords

  • Infraorbital
  • Nerve Neuropathy
  • Nerve sprouting
  • Trigeminal ganglion

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