Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers

Sarit Anavi, Zecharia Madar, Oren Tirosh*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

24 Scopus citations


Nonalcoholic fatty liver diseases (NAFLD) is one of the most common chronic liver disease in Western countries. Oxygen is a central component of the cellular microenvironment, which participate in the regulation of cell survival, differentiation, functions and energy metabolism. Accordingly, sufficient oxygen supply is an important factor for tissue durability, mainly in highly metabolic tissues, such as the liver. Accumulating evidence from the past few decades provides strong support for the existence of interruptions in oxygen availability in fatty livers. This outcome may be the consequence of both, impaired systemic microcirculation and cellular membrane modifications which occur under steatotic conditions. This review summarizes current knowledge regarding the main factors which can affect oxygen supply in fatty liver.

Original languageAmerican English
Pages (from-to)386-392
Number of pages7
JournalRedox Biology
StatePublished - Oct 2017

Bibliographical note

Funding Information:
This review was supported by an Israel Science Foundation Grant 371/12 to OT and ZM.

Publisher Copyright:
© 2017 The Authors


  • Fatty liver
  • Inflammation
  • Nitric oxide
  • Oxygen


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