Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers

Sarit Anavi, Zecharia Madar, Oren Tirosh*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

27 Scopus citations

Abstract

Nonalcoholic fatty liver diseases (NAFLD) is one of the most common chronic liver disease in Western countries. Oxygen is a central component of the cellular microenvironment, which participate in the regulation of cell survival, differentiation, functions and energy metabolism. Accordingly, sufficient oxygen supply is an important factor for tissue durability, mainly in highly metabolic tissues, such as the liver. Accumulating evidence from the past few decades provides strong support for the existence of interruptions in oxygen availability in fatty livers. This outcome may be the consequence of both, impaired systemic microcirculation and cellular membrane modifications which occur under steatotic conditions. This review summarizes current knowledge regarding the main factors which can affect oxygen supply in fatty liver.

Original languageAmerican English
Pages (from-to)386-392
Number of pages7
JournalRedox Biology
Volume13
DOIs
StatePublished - Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 The Authors

Keywords

  • Fatty liver
  • Inflammation
  • Nitric oxide
  • Oxygen

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